Publications
Research project “Neoplastic stem cells and innovative therapies”
Colaluca IN, Tosoni D, Nuciforo P, Senic-Matuglia F, Galimberti V, Viale G, Pece S, Di Fiore PP. NUMB controls p53 tumour suppressor activity. Nature 2008; 451:76-80.
https://pubmed.ncbi.nlm.nih.gov/18172499/
Westhoff B, Colaluca IN, D'Ario G, Donzelli M, Tosoni D, Volorio S, Pelosi G, Spaggiari L, Mazzarol G, Viale G, Pece S, Di Fiore PP. Alterations of the Notch pathway in lung cancer. PNAS 2009; 106 (52): 22293-22298.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799768/
Rustighi A, Tiberi L, Soldano A, Napoli M, Nuciforo P, Rosato A, Kaplan F, Capobianco A, Pece S, Di Fiore PP, Del Sal G. The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer. Nat Cell Biol 2009; 11 (2): 133-142.
https://pubmed.ncbi.nlm.nih.gov/19151708/
Confalonieri S, Quarto M, Goisis G, Nuciforo P, Donzelli M, Jodice G, Pelosi G, Viale G, Pece S, Di Fiore PP. Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor. Oncogene 2009; 28 (33): 2959-2968.
https://pubmed.ncbi.nlm.nih.gov/19543318/
Viale A, De Franco F, Orleth A, Cambiaghi V, Giuliani V, Bossi D, Ronchini C, Ronzoni S, Muradore I, Monestiroli S, Gobbi A, Alcalay M, Minucci S, Pelicci PG. Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells. Nature 2009; 457(7225):51-6.
https://pubmed.ncbi.nlm.nih.gov/19122635/
Cicalese A, Bonizzi G, Pasi CE, Faretta M, Ronzoni S, Giulini B, Brisken C, Minucci S, Di Fiore PP, Pelicci PG. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 2009; 138:1083-95.
https://www.sciencedirect.com/science/article/pii/S009286740900840X?via%3Dihub#aep-acknowledgment-id20
Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG, Di Fiore PP. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 2010; 140 (1): 62-73.
https://www.sciencedirect.com/science/article/pii/S0092867409015542?via%3Dihub
Gruszka AM, Lavorgna S, Consalvo MI, Ottone T, Martinelli C, Cinquanta M, Ossolengo G, Pruneri G, Buccisano F, Divona M, Cedrone M, Ammatuna E, Venditti A, de Marco A, Lo-Coco F, Pelicci PG. A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias. Blood 2010; 116(12):2096-102.
https://www.sciencedirect.com/science/article/pii/S0006497120329591?via%3Dihub#ceack10
Amson R, Pece S, Lespagnol A, Vyas R, Mazzarol G, Tosoni D, Colaluca I, Viale G, Rodrigues-Ferreira S, Wynendaele J, Chaloin O, Hoebeke J, Marine JC, Di Fiore PP, Telerman A. Reciprocal repression between P53 and TCTP. Nat Med. 2011 Dec 11;18(1):91-9.
https://pubmed.ncbi.nlm.nih.gov/22157679/
Insinga A, Cicalese A, Faretta M, Gallo B, Albano L, Ronzoni S, Furia L, Viale A and Pelicci PG DNA damage in stem cells activates p21, inhibits p53 and induces symmetric self-renewing divisions. Proc Natl Acad Sci U S A 2013, 110(10):3931-6.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593901/
Furia L, Pelicci PG and Faretta M. A computational platform for robotized fluorescence microscopy (I): High‐content image‐based cell‐cycle analysis. Cytometry A. 2013, 83(4):333-43.
https://onlinelibrary.wiley.com/doi/full/10.1002/cyto.a.22266
Furia L, Pelicci PG and Faretta M. A Computational Platform for Robotized Fluorescence Microscopy (II): DNA damage, replication, checkpoint activation and cell cycle progression by high-content high-resolution multiparameter image-cytometry. Cytometry A. 2013;83(4):344-55.
https://onlinelibrary.wiley.com/doi/full/10.1002/cyto.a.22265
Tosoni D, Zecchini S, Coazzoli M, Colaluca I, Mazzarol G, Rubio A, Caccia M, Villa E, Zilian O, Di Fiore PP, Pece S. The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells. J Cell Biol. 2015 Nov 23;211(4):845-62.
https://pubmed.ncbi.nlm.nih.gov/26598619/
Dama E, Tillhon M, Bertalot G, de Santis F, Troglio F, Pessina S, Passaro A, Pece S, de Marinis F, Dell'Orto P, Viale G, Spaggiari L, Di Fiore PP, Bianchi F, Barberis M, Vecchi M. Sensitive and affordable diagnostic assay for the quantitative detection of anaplastic lymphoma kinase (ALK) alterations in patients with non-small cell lung cancer. Oncotarget. 2016 Jun 14;7(24):37160-37176.
https://pubmed.ncbi.nlm.nih.gov/27206799/